Parasitic worms found in freshwater fish in Thailand can lead to a rare type of liver cancer in people who eat raw fish, with one province logging the world’s highest rate of new cases, a study found.An estimated 6 million people are infected with the parasite, commonly known as fluke, in Thailand. High rates also have been observed in neighboring Laos, where a traditional dish is made from raw fish, according to the study in the online journal PLoS Medicine.
The worm, endemic in the Mekong River countries of Thailand, Laos, Vietnam and Cambodia, is ingested through the fish and attaches to the liver. Over several decades, the infection can create ulcers and inflammation leading to tumors and cholangiocarcinoma, or cancer of the bile ducts. Most patients typically develop cancer in their 40s or 50s.
“It is quite slow growing. But when it turns out to be cancer, it is very rapid,” said lead author Banchob Sripa of Khon Kaen University’s Pathology Department in Thailand. “If you start out getting diagnosed today, maybe in the next six months you will die.”
He said fluke attack the human bile duct and the incursion triggers a “cytokine storm” — an immune response so intense that it destroys not only the parasites, but the person’s surrounding tissues as well.
“There are two mechanisms. The fluke has two suckers. It can bite the surface epithelium of the bile duct and cause ulcers. The second is the inflammation,” Banchob said. “The ones with more inflammatory cytokines may have more inflammation … and these may develop cancer later on.”
The disease is rare, making up less than 1 percent of all cancers worldwide in 2002. But it is much more common in Khon Kaen province, where liver cancer strikes nearly one in 1,000 men — nearly all cases bile duct cancer. Women are three times less likely to develop the disease, Banchob said.
Koi-pla, the Thai name for a dish of minced raw fish mixed with hot chilies and local spices, is a staple in Khon Kaen. The fish are typically caught in rivers or ponds that are often contaminated by untreated sewage.
The worm can be eliminated from humans with praziquantel, a drug that is cheap and easily available. But another recent study showed that even though about half of those surveyed in Khon Kaen province had taken the pill at some point, the parasite was still present in about 30 percent, said Banchob.